A receiver multi-protocol interface includes a wide bandwidth amplifier, a data sampling module, and a clocking module. The wide bandwidth amplifier amplifies a first formatted input signal or a second formatted input signal to produce an amplified input signal. The data sampling module converts the amplified input signal into a first data stream in accordance with at least one first sampling clock signal when the interface is configured in the first mode and to converts the amplified input signal into a second data stream in accordance with at least a second sampling clock signal when the interface is in a second mode. The clocking module generates the first sampling clock signals from a reference clock when the multi-protocol interface is in a first operational mode and generates the second sampling clock signals based on the reference clock when the interface is in the second operational mode.