The present invention relates to compounds with structures resembling natural statins isolated from Penicillium sp. (Formula I); where R.sub.1 represents OH, C.sub.6H.sub.5COO, R.sub.6COO and R.sub.6 represents C.sub.1 C.sub.5 alkyl; R.sub.2-4 represents H, C.sub.1 C.sub.5 alkyl C.sub.1 C.sub.5 acyl, R.sub.5 represents H, CH.sub.3; and X represents a compound of (Formula II) or (Formula III) ##STR00001##