Disclosed herein are endoscopic gastric restriction devices and methods. In one embodiment, the device generally includes a shaft having an end effector on a distal end thereof. The end effector includes several elongate segments that are coupled to one another and include opposed troughs formed therein. Each trough is configured to suction and pull tissue into the trough, as well as hold a fastener that can be delivered to tissue disposed within the trough. As a result, the end effector can deliver multiple fasteners to opposed walls of tissue. As the fasteners are delivered into tissue, the segments can be detached from the device, so that the end effector remains in the tissue. Over time, the end effector can be absorbed and/or dissolve, leaving the fasteners behind.