The present invention relates to an anti-inflammatory and COX-2 inhibitory composition that contains at least one of cold-pressed edible seed oils, flours and/or their derivatives having anti-inflammatory and COX-2 inhibitory activity as an active ingredient. The seed oils can be derived from at least one of red raspberry, black raspberry seed, black cumin seed, caneberry seed, raspberry seed, blackberry seed, marionberry seed, boysenberry seed, evergreen blackberry seed, coriander seed, sea buckthorn seed, palm fruit seed, cardomon seed, evening primrose seed, cranberry seed, mullein seed, parsley seed, carrot seed, blueberry seed, grape seed, chardonnay grape seed or merlot grape seed.