A machine for intraoperative radiation therapy or IORT (Intra Operative Radio Therapy), includes a mobile body, having at least two driving wheels and at least an idle wheel, each driving wheel being operated by a corresponding moving engine, the machine including a radiating head connected to the body, for emitting an electron beam, handling elements which are integral with the radiating head, engine unit for moving the radiating head, for impressing to the radiating head at least a vertical translation motion. The handling elements include at least three bidirectional sensors, for measuring both a traction stress and a compression stress, each of which sends to a control processor an electric signal proportional to a measured stress which is orthogonal to the sensor. The control processor operates the moving engines of each driving wheel and the engine unit proportionally to the stresses measured by the at least three bidirectional sensors.