Novel polycyclic compounds having the structural formula (I) below: ##STR00001## are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

 
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> Human and rat PGC-3, PPAR-gamma coactivations and splice variants thereof

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