The present invention is related to hybrid conjugates formed by covalently
bonding siRNA (small interfering RNA) molecules to hydrophilic polymers
for improving stability of the siRNA molecules effective for delivering
the siRNA in vivo, and polyelectrolyte complex micelles formed by ionic
interactions between the conjugates and multifunctional cationic
compounds. The siRNA-hydrophilic polymer conjugates and polyelectrolyte
complex micelles derived therefrom can be used for improving stability of
the siRNA molecules in vivo. Consequently, the delivery of siRNA
molecules for therapeutic applications into cells can be facilitated, and
the siRNA is still active even though a small dose of the siRNA is used.