The present invention provides: a therapeutic and/or preventive agent for
chronic skin diseases which comprises (a) a phosphodiesterase (PDE)-IV
inhibitor or a pharmaceutically acceptable salt thereof and (b) a steroid
agent as active ingredients; a therapeutic and/or preventive agent for
chronic skin diseases to be administered simultaneously or separately
with an interval which comprises (a) a PDE-IV inhibitor or a
pharmaceutically acceptable salt thereof and (b) a steroid agent, as
active ingredients; a kit for treating and/or preventing chronic skin
diseases characterized by comprising (a) a first component comprising a
PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a
second component comprising a steroid agent; and the like.