the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 1 or 2; M represents a direct bond or a C.sub.1-3alkyl linker optionally substituted with one or two substituents selected from C.sub.1-4alkyl, C.sub.1-3alkyloxy-C.sub.1-4alkyl-, hydroxy-C.sub.1-4alkyl-, hydroxy, C.sub.1-3alkyloxy- or phenyl-C.sub.1-4alkyl-; R.sup.1 and R.sup.2 each independently represent hydrogen, halo, cyano, hydroxy, C.sub.1-4alkyl optionally substituted with halo, C.sub.1-4alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy, Ar.sup.1 and halo; R.sup.3 represents hydrogen, halo, C.sub.1-4alkyl, C.sub.1-4alkyloxy-, cyano or hydroxy; R.sup.4 represents hydrogen, halo, C.sub.1-4alkyl, hydroxy, cyano or C.sub.1-4alkyloxy-optionally substituted with one or where possible two or three substituents selected from hydroxy and halo; R.sup.5 represents hydrogen, C.sub.1-4alkyl or Ar.sup.2--C.sub.1-4alkyl-; R.sup.6 represents hydrogen, hydroxy, halo, C.sub.1-4alkyl or C.sub.1-4alkyoxy-; R.sup.7 represents hydrogen or R.sup.7 and R.sup.5 taken together with the carbon atom to which they are attached from a --C.sub.2-alkyl-linker; Ar.sup.1 and Ar.sup.2 each independently represent phenyl or naphtyl wherein said phenyl and naphtyl are optionally substituted with C.sub.1-4alkyl, C.sub.1-4alkyloxy-, or phenyl-C.sub.1-4alkyl.

 
Web www.patentalert.com

> Articulating anastomotic ring applier

~ 00399