Phosphopeptides containing the Ser(P) cluster sequence motif
Ser(P)-Ser(P)-Ser(P)-Glu-Glu- can stabilize their own weight in amorphous
calcium phosphate (ACP)
[Ca.sub.3(PO.sub.4).sub.1.87(HPO.sub.4).sub.0.2xH.sub.2O] and amorphous
calcium fluoride phosphate (ACFP) [Ca.sub.8(PO.sub.4).sub.5F x H.sub.2O].
The amorphous phases stabilised by the phosphopeptides are an excellent
delivery vehicle to co-localise Ca, F, and phosphate at the tooth surface
in a slow-release amorphous form producing superior anticaries efficacy.
These amorphous phases stabilised by the phosphopeptides also have
utility as dietary supplements to increase calcium bioavailability and to
help prevent diseases associated with calcium deficiencies.