The present invention relates to a simple and effective method for
preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl
sustained-release tablet produced thereby. The method comprises the steps
of: dissolving tamsulosin HCl as an active ingredient in an organic
solvent; dissolving the tamsulosin HCl solution in
hydroxypropylmethylcellulose phthalate to prepare a binder solution; and
kneading the binder solution with a hydroxypropylmethylcellulose
phthalate/glyceryl dibehenate mixture as an excipient and allows
tamsulosin HCl to be released at uniformly controlled amounts in a
subtained-release manner in vivo by controlling drug release rate
according to different pH environments in vivo, so that it shows improved
bioavailability and minimized side effects.