One illustrative method of reducing signal interference in a wireless receiver includes receiving a radio frequency (RF) signal; amplifying the received RF signal with a gain G; producing a baseband signal from the amplified RF signal; producing a signal-to-interference (S/I) ratio from the baseband signal; and adjusting the gain G based on the S/I ratio. Preferably, the gain G is varied over a time period to produce a plurality of S/I ratios, so that the gain G corresponding a maximum S/I ratio produced over the time period can be selected for optimal performance. With this technique, higher accuracy is provided as intermodulation distortion is accounted for in the S/I ratio. Advantageously, the S/I ratio calculations and the gain adjustments are performed digitally by one or more processors such as a digital signal processor (DSP).