Devices and methods for treating patients suffering from an eating disorder, such as obesity and/or pathologies resulting in obesity, by regulating sensations affecting food consumption. The devices and methods may facilitate appropriate caloric intake, thereby inducing weight loss, by simulating, stimulating, amplifying, blocking and/or modulating signals in the gastrointestinal (GI) tract and/or nerves innervating the GI tract, to manage sensations of hunger and satiety, such as controlling hunger by signaling the gastrointestinal tract and/or gastrointestinal nerves when different hunger sensations are detected.