The invention relates to novel synthesis methods for the preparation of
the intermediates, which are suitable for the preparation of statin
derivatives, especially to novel synthesis methods of the intermediate of
formula VI wherein R.sub.a' and R.sub.c' are each independently of the
other hydrogen or a hydroxy-protecting group or together are a bridging
hydroxy-protecting group, and R.sub.b is a carboxy-protecting group,
which methods are carried out by conversion of the intermediate of
formula XVI wherein R.sub.a' and R.sub.c' are each independently of the
other hydrogen or a hydroxy-protecting group, R* and R** are each
independently of the other hydrogen or an amide-protecting group, and
R.sub.b is a carboxy-protecting group; which methods proceed to further
new intermediates and methods for their preparation ##STR00001##