Compounds of formula I or II are provided, wherein R.sub.1-R.sub.8 are defined herein, and pharmaceutical compositions and kits containing these compounds. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I, formula II, or formula III, wherein R.sub.1-R.sub.9 are defined herein: ##STR00001##