A herbal formulation used for treatment of depression and other related disorders comprises the following ingredients, namely Os Draconis, Concha Ostreae, Fructus Tritici Aestivi, Bulbus Lilii, Radix Rehmanniae, Caulis Polygoni Multiflori, Fructus Jujubae, Flos Albiziae, Radix Et. Rhizoma Glycyrrhizae Praeparata Cum Melle, Sclerotium Poriae Circum Radicem Pini, Caulis Bambusae in Taenia, and Rhizoma Zingiberis Recens.