The present invention relates to a group of
1H-1,2,4-triazole-3-carboxamide derivatives, to methods for the
preparation of these compounds, and to pharmaceutical compositions
containing at least one of these compounds as an active ingredient.These
1H-1,2,4-triazole-3-carboxamide derivatives are potent
cannabinoid-CB.sub.1 receptor agonists, partial agonists, inverse
agonists or antagonists, useful for the treatment of disorders involving
cannabinoid neurotransmission.The compounds have the general formula (I)
##STR00001## wherein R and R.sub.1-R.sub.3 have the meanings given in
the specification.