Materials and method are disclose for delivering a desired substance to a
target site, using a layered carrier in which the carrier and the
substance together form at least three layers which associate by ionic
interaction at the first pH, where at least one layer comprises a charge
switch material which comprises an ionisable group and which has a
positive charge at a first pH and a charge which is less positive,
neutral or negative at a second pH, at least one layer comprises a
polyionic polymer which is negatively charged at the first pH and at
least one layer comprises the desired substance. Preferred carriers are
based on the charge switch material poly Bis-Tris and the polyionic
polymer polyacrylic acid.