Replication of application files in a clustered environment may be automated based on the state and/or configuration of the application in the cluster. A clustering engine executing on one or more clustered computing nodes may notify one or more replication agents regarding changes in a clustered application's state and/or configuration. An application's status may include information indicating one or more cluster nodes on which the application is currently executing and also may include information indicating one or more cluster nodes on which the application is configured to execute. Replication agents executing on cluster nodes may, either individually or through collective coordination, modify a replication policy for replicating one or more application files based on the received status information. Subsequently, the replication agents may replicate the application files from one of the clustered computing nodes to one or more other nodes, according to the modified replication policy.