A seal structure for a vehicle, which includes a door member and a seal member attached thereto. The seal member includes a horizontally extending upper seal lip which comes into elastic contact with a peripheral part of an opening provided on a vehicle body, and a vertically extending side seal lip which comes into elastic contact with another peripheral part of the opening. The upper seal lip and side seal lip are connected to each other by die forming, thus forming a connected portion thereof. The upper seal lip and side seal lip have, on a side of the connected portion to be proximate to the vehicle body when the door member is closed, a seal sheet member covering the connected portion.