In a method and magnetic resonance apparatus for generation of a measurement sequence that can be executed with the hardware of the magnetic resonance apparatus, a measurement sequence is generated as a series of time slices of different time slice types, with the control signals for the magnetic resonance apparatus during each time slice being determined using parameters describing these time slices. After division of the measurement sequence into a number of time slices dependent on the sequence type and on a k-space sampling type, descriptive variables are associated with the time slices. Value ranges of the variables are limited and/or the variables are set in relation to one another using boundary conditions. A determination ensues of solution values of the variables with which a predetermined target parameter of the measurement sequence is optimized. A measurement sequence executable on the hardware is attained by association of the solution values with the corresponding parameters of the time slices.