The present invention describes various devices and methods wherein a
cytostatic antiproliferative drug, either alone or in combination with
other drugs, is placed between internal body tissues to prevent the
formation of scar tissue and/or adhesions during healing of a wound or
surgical site. Specific devices to achieve this administration include,
but are not limited to, a permanent implant or a biodegradable material
having an attached antiproliferative drug such as sirolimus. These
antiproliferative drugs may be combined with other drugs including, but
not limited to, antiplatelets, antithrombotics or anticoagulants. The
present invention also contemplates methods to a reduce scar tissue
and/or adhesions or adhesion formation at an anastomosis site. In
particular, a cytostatic antiproliferative drug is administered to an
arteriovenous shunt anastomoses in patients having end-stage renal
disease.