Disclosed are diagnostic techniques for the detection of human disease
states that affect gene expression in peripheral leukocytes. The
invention relates particularly to probes and methods for evaluating the
presence of RNA species that are differentially expressed in the
peripheral blood of individuals with such a disease state compared to
normal healthy individuals. The invention further relates to methods for
detection of protein species that are differentially expressed in the
peripheral blood of individuals with such a disease state compared to
normal healthy individuals. Genetic probes, antibody probes and methods
useful in monitoring the progression and diagnosis of two specific
disease states, prostatic cancer and breast cancer, are described.