A root canal is filled and/or sealed using a hydrophilic sealing composition, optionally in combination with other filling materials. The sealing composition may include one or more resins that promote adhesion to hydrophilic dental tissues. The composition may be introduced into the root canal using a narrow cannula coupled to a high pressure hydraulic delivery device. In the case where a chemical cure composition is used to seal the root canal, a chemical initiator can be used to cause the mixed composition to harden over time. Hardening of at least a portion of the composition can be accelerated by including a photoinitiator and irratiating the mixed composition with radiant energy (e.g., from a dental curing lamp).