This invention provides a novel immunogenic composition and vaccine,
processes for producing them and methods for immunization against
infections and disease caused by group A Streptococci. The compositions
include group A streptococcal polysaccharide covalently linked to protein
or liposomes to form immunogenic conjugates. The method of immunization
for this invention comprises administering to an individual an
immunogenic amount of group A polysaccharide. The group A polysaccharide
may be administered as a vaccine either on its own, conjugated to
proteins or conjugated to liposomes. Additionally, the group A
polysaccharides may be associated with an adjuvant. This invention is
particularly useful for providing both active and passive immunogenic
protection for those populations most at risk of contracting group A
Streptococcal infections and disease namely adults, pregnant women and in
particular infants and children.