The invention relates generally to compositions and devices for the inactivation of pharmaceuticals, such as narcotics, to facilitate waste disposal, and methods thereof. In some aspects, a reaction chamber comprising a fluorescent whitening agent is used to generate hydrogen peroxide in the presence of ultraviolet light. In a preferred embodiment, a stilbene-based fluorescent whitening agent is used. The ensuing chemical reaction inactivates pharmaceuticals, such as narcotics, by cleaving benzene ring structures in some embodiments. The inactivated narcotics can then be disposed of according to conventional medical waste disposal processes, thereby facilitating compliance with both environmental and drug enforcement laws and regulations.