A mattress pad positionable atop a rectangular mattress which better accommodates diverse weights and sizes of the human anatomy for enhanced comfort. The mattress pad includes a flexible air tight bottom sheet having a size and shape substantially similar to that of a top surface of the mattress. A flexible air tight top sheet is connected to the bottom sheet by peripheral heat or ultrasonic weld sealing along common perimeter side, head and foot margins. A plurality of generally side-by-side body supporting chambers are each defined by peripheral sealing lines and spaced lines of continuous sealing which interconnect the top and bottom sheets. Each air chamber is individually and selectively fillable with pressurized air and thus capable of localized pressurization within the chamber. Preselected nominal thicknesses of each of the chambers provides the comfort and accommodation to each portion of the human anatomy.