A latching assembly includes a removable panel (1), a knob (2), a sliding latch (3), and a base cover (5). The removable panel includes a mounting hole (12), a depression portion (13), and a plurality of catches (17). The knob includes a slanted protuberance (22), and the knob mates in the mounting hole. The sliding latch includes a head portion (32), a slanted portion (38), and a spring arm (34). The base cover includes a slot (51) matingly receiving the head portion, a plurality of catch slots (54) matingly receiving the catches, and a board (53). When the knob is pressed, the slanted protuberance engages with the slanted portion and the spring arm can move in the depression portion. As a result, the removable panel can be fixed on the base cover or released from the base cover easily.