A method, arrangement and computer program is described for generating a database of selectable fresh fuel bundle designs usable in one or more nuclear reactors. In an example, an initial population of candidate fresh fuel bundle designs may be generated and a set of rod-type changes to make to a given candidate in the initial population may be established. A given candidate fresh fuel bundle may be modified by making at least one rod-type change from the set therein. A core loaded with the modified bundle design may be simulated to generate bundle performance outputs. The bundle performance outputs may be ranked based on a plurality of user-input limits. The modified candidate fresh fuel bundle design may be stored, if the bundle performance outputs meet, or are within an accepted margin to, the user-input limits, so as to generate the database.