A running wheel arrangement for a wheelchair that can be driven by electric motor including a frame and wheels releasably connected. A driving motor being integrated in two wheels and the wheels are connected via a respective adapter arranged on the frame. The wheel is inserted into the adapter and mechanically lockable via a locking device which includes: a pivot plate fastened to the driving motor; the wheel is mounted rotatably in a pivot plate via an axle bolt; a link bolt pointing in the direction of travel arranged in the adapter; a cross-sectionally U-shaped tab arranged at one end of the pivot plate; the tab being placed onto the link bolt such that the wheel is shifted by means of a pivoting movement toward the frame until a locking bolt provided on the pivot plate engaged on the locking bush arranged on the adapter, and the wheel is locked mechanically with respect to the frame via the locking bolt and the locking bush.