The present invention relates to compounds of formula (I), and
pharmaceutically acceptable salts, prodrugs, solvates and crystalline
forms thereof, in which R.sup.1 and R.sup.2 independently represent: a
C.sub.1-6alkyl group; an optionally substituted
(amino)C.sub.1-4alkyl-group; an optionally substituted non-aromatic
C.sub.3-15carbocyclic group; a
(C.sub.3-12cycloalkyl)C.sub.1-3alkyl-group; a group
--(CH.sub.2).sub.r(phenyl).sub.s in which r is 0, 1, 2, 3 or 4, s is 1
when r is 0 otherwise s is 1 or 2 and the phenyl groups are optionally
independently substituted by Z; naphthyl; anthracenyl; an optionally
substituted saturated 5 to 8 membered heterocyclic group containing one
nitrogen and optionally one of the following: oxygen, sulphur or an
additional nitrogen; 1-adamantylmethyl; a group --(CH.sub.2).sub.t Het in
which t is 0, 1, 2, 3 or 4, and the alkylene chain is optionally
substituted and Het represents an optionally substituted aromatic
heterocycle; or R.sup.1 represents H and R.sup.2 is as defined above; or
R.sup.1 and R.sup.2 together with the nitrogen atom to which they are
attached represent a saturated optionally substituted 5 to 8 membered
heterocyclic group as defined above; X is CO or SO.sub.2; Y is absent or
represents NH optionally substitututed by a C.sub.1-3alkyl group; R.sup.3
and R.sup.4 independently represent phenyl, thienyl or pyridyl
substituted by Z; Z represents a C.sub.1-3alkyl group, a C.sub.1-3alkoxy
group, hydroxy, halo, trifluoromethyl, trifluoromethylthio,
trifluoromethoxy, trifluoromethylsulphonyl, nitro, amino, mono or di
C.sub.1-3alkylamino, mono or di C.sub.1-3alkylamido,
C.sub.1-3alkylsulphonyl, C.sub.1-3alkoxycarbonyl, carboxy, cyano,
carbamoyl, mono or di C.sub.1-3alkyl carbamoyl, sulphamoyl and acetyl;
and R.sup.5 is H, a C.sub.1-3alkyl group, a C.sub.1-3alkoxymethyl group,
trifluoromethyl, a hydroxyC.sub.1-3alkyl group, C.sub.1-3alkoxycarbonyl,
carboxy, cyano, carbamoyl, mono or di C.sub.1-3alkylcarbamoyl, acetyl, or
hydrazinocarbonyl of formula --CONHNR.sup.aR.sup.b; with the provisos;
and processes for preparing such compounds, their use in the treatment of
obesity, psychiatric and neurological disorders, to methods for their
therapeutic use and to pharmaceutical compositions containing them.
