In a preferred embodiment, drugs having chemotherapeutic properties which are useful against certain neoplastic disorders with wide safety margins as evidenced by their low toxicity, and molecular actions. Such drugs include as active ingredient(s) one or more N-substituted 2-(1H) pyridone(s) and/or N-substituted 3-(1H) pyridone(s). The compositions of this invention are novel as anti-neoplastic drugs, namely .[.as an agent for treating leukemias, lymphomas, and leiomyomas.]. .Iadd.as agent(s) for treating benign and malignant tumors, including lymphomas, leukemias, and leiomyomas.Iaddend..