An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic
compound of formula I, pharmaceutical composition comprising same, and a
method of treating one or more CNS or other disorders, including
concurrent treatment of disorders such as schizophrenia and depression,
wherein formula I is ##STR00001## or a pharmaceutically acceptable salt
or thereof, wherein Z is ##STR00002## wherein Y is methylene; X is
oxygen; n is 0; R.sup.1 and R.sup.2 are each hydrogen or halogen; and
R.sup.3 and R.sup.4 together with the nitrogen atom to which they are
attached form i) a saturated non-aromatic 3 to 7 membered monocyclic
ring, said ring i) being unsubstituted or substituted or substituted with
one or more (C.sub.1 C.sub.4)alkyl, (C.sub.1 C.sub.4)alkoxy(C.sub.1
C.sub.4)alkyl, or hydroxy groups.