Provided are methods for preventing post-operative neovascularization and/or inflammation in ophthalmic tissue of a patient undergoing ophthalmic surgery by administering a therapeutically effective amount of an anti-VEGF compound to the ophthalmic tissue of a patient where the anti-VEGF compound is administered to the patient prior to the time the ophthalmic surgery is performed on the patient to one hour following the time the ophthalmic surgery is performed on the patient.