Methods and apparatus for optimizing memory accesses in a circuit design are described. According to one embodiment, a method comprises identifying a subset of variables from a multi-variable memory space that are accessed by a plurality of loops, storing the subset of variables in a separately accessible memory space, and accessing one of the stored subset of variables to recover a stored value of the one of the stored subset of variables for use by at least one of the plurality of loops during synthesis. According to another embodiment, a method comprises identifying at least a first loop and a second loop, determining whether a dependency exists between the first loop and the second loop, and merging the first loop and the second loop into a single merged loop, wherein the merging comprises mapping a plurality of memory accesses from the first loop to a sliding window.