A PWM (pulse width modulation) boost system includes a boost circuit, a voltage dividing circuit, a comparator, a PWM circuit, a pre-oscillator, and a current limit circuit. A start-up method of the PWM boost system includes (1) providing an error voltage; (2) generating a PWM signal according to the error voltage; (3) controlling a switch in a boost circuit with the PWM signal, so as to control an inductor current flowing through a boost inductor in the boost circuit; (4) charging a capacitor in the boost circuit with the inductor current, wherein charges stored in the capacitor define a DC output voltage; and (5) providing a feedback voltage according to the DC output voltage to adjust the error voltage.