In a data processing system utilizing multiple page sizes for virtual memory paging, a system, method, and article of manufacture for managing page replacement. In one embodiment, the page replacement method begins with a page frame allocation request, such as may be generated following a page fault. A page replacement procedure is invoked to select one or more pages to be replaced by the requested page(s). In a preferred embodiment, the page replacement includes a step of selecting, in accordance with a page type allocation of at least one of the multiple page sizes, a page size to be utilized for page replacement for the page frame allocation request.