A wheelchair seat cushion has multi-density regions. The cushion assembly may have a region having a stiffer, higher density proximate the front of the seat cushion assembly beneath the user's thighs to assist the user in exiting the wheelchair. Alternatively, or additionally, an insert member having multi-density regions may be received in a recess in a base member. The insert members may be oriented in different orientations to position a softer, less dense region at different locations, to situate the softer, less dense region of the insert beneath a particular user's ischial tuberosities and/or coccyx.