The present invention is directed to a biological conjugate, comprising:
(a) a targeting moiety comprising a polypeptide having an amino acid
sequence comprising the polypeptide sequence of SEQ ID NO:2 and the
polypeptide sequence of a selected targeting protein; and (b) a binding
moiety bound to the targeting moiety; the biological conjugate having a
covalent bond between the thiol group of SEQ ID NO:2 and a functional
group in the binding moiety. The present invention is directed to a
biological conjugate, comprising: (a) a targeting moiety comprising a
polypeptide having an amino acid sequence comprising the polypeptide
sequence of SEQ ID NO:2 and the polypeptide sequence of a selected
targeting protein; and (b) a binding moiety that comprises an adapter
protein, the adapter protein having a thiol group; the biological
conjugate having a disulfide bond between the thiol group of SEQ ID NO:2
and the thiol group of the adapter protein. The present invention is also
directed to biological sequences employed in the above biological
conjugates, as well as pharmaceutical preparations and methods using the
above biological conjugates.