There is disclosed a method of inhibiting the lethal effect of expressing
an otherwise lethal protein in a cell, said method comprising: (a)
providing a cell, tissue or organism having (i) a nucleotide sequence
encoding a Gas1 protein, or a functional equivalent, derivative or
bioprecursor thereof, which is capable of inducing apoptosis in said cell
and (ii) a further nucleotide sequence encoding a protein which is
otherwise lethal to said cell in itself or in response to a lethal
stimulus in the presence of Gas1; (b) inhibiting function and/or
expression of said Gas1 protein or functional equivalent, derivative or
bioprecursor thereof; and (c) expressing said sequence encoding said
otherwise lethal protein.