The present invention relates to a method for producing optically active
IHOG, which can in turn be used for the production of monatin. The
present invention further relates to a method for producing optically
active monatin, and an aldolase which can be used in these methods. As
such, the present invention enables the synthesis of
4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical
purity, which is useful as an intermediate in the synthesis of optically
active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic
acid).