A joint aspirate-facilitating device is provided including a flexible main panel that is secured to the joint to be aspirated. An inflatable bladder is secured to the main panel and is placed in contact with the soft tissues overlying and surrounding the joint space. The bladder is used to apply pressure to selected areas of the joint to compress the fluid sacs in the joint. An access opening is formed in the main panel designating the location where joint fluid is to be aspirated. The joint fluid is directed to flow to the area of the joint exposed at the access opening based on the shape of the bladder that compresses surrounding areas of the fluid sacs. A conventional hand pump may pressurize the bladder or the bladder may be filled with a viscous gel material to generate pressure. Multiple access openings may be formed on the main panel designating locations where aspiration is to be conducted. For multiple access openings, plugs may be used to fill those openings where aspiration is not conducted, thereby maximizing joint fluid flow only to the selected location where aspiration is to be conducted. An ultrasound probe may be attached and incorporated into the device to confirm joint fluid displacement into the targeted location prior to need aspiration. A disposable molded sterile dressing may applied to the access opening to reduce the risk of infections. The device can be used on any joint of the body, and the particular shape of the main panel and bladder accommodates maximum joint fluid flow to the point where aspiration is desired.