Various embodiments of the present invention are directed to antisymmetric nanowire-crossbar-circuit designs. Antisymmetric nanowire crossbars are composed, in certain embodiments of the present invention, of two or more microregions that receive input signals and two or more microregions that send output signals. Antisymmetric nanowire crossbars may include a nanowire-crossbar network having signal paths that carry signals between one or more of the microregions. The nanowire-crossbar network may also carry signals between external electronic devices and one or more of the microregions. Antisymmetric nanowire crossbars may additionally include two or more structures that supply voltage and ground.