A vehicle power transmission system comprises: a prime mover mounted on a vehicle body frame; a first axle and a first transaxle for driving the first axle disposed at one of front and rear portions of a vehicle, the first transaxle having a first input part projecting outward therefrom, and the first transaxle having a power take-off shaft projecting outward therefrom opposite to the first input part; a speed-changing transmission drivingly interposed between the prime mover and the first input part; a second axle and a second transaxle for driving the second axle disposed at the other rear or front portion of the vehicle, the second axle having a second input part; and a power take-off train extended from a leading part to an ending part. The prime mover is disposed between the first transaxle and the second transaxle in a fore-and-aft direction of the vehicle. The leading part of the power take-off train is drivingly connected to the power take-off shaft, and the ending part of the power take-off train is drivingly connected to the second input part. The leading part of the power take-off train is separated from the first transaxle and laterally offset from the prime mover.