Embodiments of the invention provide a method, article of manufacture, and system of detecting a cryogenic leak. In one embodiment, the method includes calibrating an infrared camera by detecting one or more first areas of low temperature in a first infrared image of a location received from the infrared camera wherein the low temperature is lower than an ambient temperature, detecting one or more second areas of low temperature in a second infrared image of the location received from the infrared camera wherein the low temperature in the second infrared image is lower than the ambient temperature and indicative of the cryogenic leak, and wherein the one or more second areas are not the one or more first areas, and in response to detecting the one or more second areas of low temperature in the second infrared image, generating an alarm message which indicates the cryogenic leak.