In a method for the production and filling of containers (12), at least one tube (3) of plasticized plastic material is extruded into an open mold (6). The tube (3) is bonded at its advancing end on closing the mold (6) to form the container base. The tube (3) is severed above the mold, by a separating element (21) to form a filling opening. The mold (6) having the tube (3) with a filling opening is moved to a filling position in which the container is filled after the tube (3) formed in the mold by generating an expanding pressure gradient acting on the tube (3). During the movement of the mold (6) into the filling position, the filling opening of the tube (3) is covered by a sterile barrier (23).