The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives
that bind to the receptor as ligands of human peroxisome
proliferator-activated receptor (PPAR) .alpha. to activate and exhibit
lipid-lowering effect, inhibitory effect on the arteriosclerosis,
antiobesity effect, blood glucose-lowering effect, etc., their addition
salts, and their medicinal compositions.(2S)-2-Ethylphenylpropanoic acid
derivatives represented by a general formula (1) ##STR00001## [wherein
R1 denotes a halogen atom or trifluoromethyl group, R2 denotes a hydrogen
atom, halogen atom or trifluoromethyl group, and, when R2 denotes a
hydrogen atom, R3 denotes a halogen atom or trifluoromethyl group and,
when R2 denotes a halogen atom or trifluoromethyl group, R3 denotes a
hydrogen atom, halogen atom or trifluoromethyl group], and their addition
salts.