The invention is a medical implantable device which is coated by the
method according to the invention. The surface of the substrate used for
the implantable device, in the raw condition, following a cleaning regime
and physiochemical pretreatments, is coated using a biomimetic process in
a supersaturated calcium phosphate solution (SCPS) to obtain the desired
coating coverage and morphology maintaining a ratio of calcium to
phosphorus pH, as well as solution temperature plays a major role in
yielding precipitation of the proper phase of CaP so that composition,
morphologies, crystal structures, and solubility characteristics are
optimal for the deposition process. The biomimetic coating adds the
attribute of osteoconductivity to the implant device. To maximize bone
growth, the implant must also induce bone growth, or possess the
attribute of osteoinductivity. This attribute is acquired by the use of
therapeutic agents, i.e. bone morphogenic proteins (BMP), growth factors,
stem cells, etc. The preparation of the SCPS solution is slightly altered
so that during the immersion of the implant in the SCPS, the therapeutic
agents are co-precipitated and bonded with the CaP directly on the
underlying surface of the implant device. A final dipping process into a
BMP solution provides an initial burst of cellular activity. For
delivering stem and/or progenitor cell, after drying the dipped solution
of BMP, the cells are cultured on the surface of the implant.