The present invention provides novel chymopapain isoenzymes, compositions thereof, and methods for locally ad-ministering recombinant chymopapain or synthetic chymopapain to treat a disc disorder. Recombinant chymopapain or synthetic chymopapain useful in the methods of the invention can be naturally occurring chymopapain or variant chymopapain, including the novel chymopapain isoenzmyes of the invention.

 
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