Recombinant papillomavirus capsid proteins that are capable of self
assembly into capsomer structures and viral capsids that comprise
conformational antigenic epitopes are provided. The capsomer structures
and viral capsids, consisting of the capsid proteins that are expression
products of a bovine, monkey or human papillomavirus L1 conformational
coding sequence proteins, can be prepared as vaccines to induce a high
titer neutralizing antibody response in vertebrate animals. The self
assembling capsid proteins can also be used as elements of diagnostic
immunoassay procedures for papillomavirus infection.